Management and prognosis of juvenile arthritis on the model of molecular genetic testing of gene p53

Introduction Juvenile idiopathic arthritis (JIA) is a multifactor chronic inflammatory joints disease that is characterized by long progressive course leading to development of contractures and loss of joint ́s function. Currently, there are only several laboratory and radiological predictors of unfavorable prognosis of JIA. In recent years, scientists studied the molecular basis of the development and maintenance of chronic inflammation in the joint. Reduced sensitivity of cells to apoptosis is one the possible mechanisms contribution to progressive inflammation in synovial membrane. Polymorphisms Arg72Pro 4 exon, ins/del 16bp intron 3 and G13964C intron 6 gene P53 may change expression gene P53 and functional activity this protein, main factor of intrinsic apoptosis pathway (P.Dumont et al 2003; A.Sallivan et al, A.Ghosh et al 2004).